Design and assembly of supramolecular dual-modality nanoprobes
نویسندگان
چکیده
منابع مشابه
Design and assembly of supramolecular dual-modality nanoprobes.
We report the design and synthesis of self-assembling dual-modality molecular probes containing both a fluorophore for optical imaging and a metal ion chelator for imaging with MRI or radionuclide methods. These molecular probes can spontaneously associate into spherical nanoparticles under physiological conditions. We demonstrate the use of these supramolecular nanoprobes for live-cell optical...
متن کاملβ3-specific Dual-modality Micellar Nanoprobes
Multimodality tumor-specific nanoprobes that incorporate two or more imaging functionalities are becoming an integral part of early detection, molecular diagnosis and post-therapy assessment of cancer (1,2). Magnetic resonance imaging (MRI) and optical imaging are two complementary imaging modalities that provide superb anatomical and functional imaging information, respectively. Here we report...
متن کاملDual-Modality, Dual-Functional Nanoprobes for Cellular and Molecular Imaging
An emerging need for evaluation of promising cellular therapies is a non-invasive method to image the movement and health of cells following transplantation. However, the use of a single modality to serve this purpose may not be advantageous as it may convey inaccurate or insufficient information. Multi-modal imaging strategies are becoming more popular for in vivo cellular and molecular imagin...
متن کاملIn vivo angiogenesis imaging of solid tumors by avb3-targeted, dual-modality micellar nanoprobes
The objective of this study was to develop and evaluate an avb3-specific nanoprobe consisting of fluorescent superparamagnetic polymeric micelles (FSPPM) for in vivo imaging of tumor angiogenesis. Spherical micelles were produced using poly(ethylene glycol)-b-poly(D,L-lactide) co-polymers conjugated with tetramethylrhodamine, a fluorescent dye, and loaded with superparamagnetic iron oxide nanop...
متن کاملIn Vivo Immunotoxicity of SiO2@(Y0.5Gd0.45Eu0.05)2O3 as Dual-Modality Nanoprobes
We have successfully synthesized SiO2@(Y0.5Gd0.45Eu0.05)2O3 nanocomposites as a potential dual-modality nanoprobe for molecular imaging in vitro. However, their immunotoxicity assessment in vivo remains unknown. In this article, the in vitro biocompatibility of our dual-modality nanoprobes was assayed in terms of cell viability and apoptosis. In vivo immunotoxicity was investigated by monitorin...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Nanoscale
سال: 2015
ISSN: 2040-3364,2040-3372
DOI: 10.1039/c5nr01518a